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596 Similarly, the quorum sensing master regulator from Pseudomonas aeruginosa PAO1 LasR binds to its target DNA and activates transcription upon modification by a sulfur-based oxidant, e.g., a thiol persulfide, which first forms a C188 persulfide or polysulfide moiety, ultimately resulting in a pentasulfide linkage between Cys201 and Cys203

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For skin-related autoimmune conditions, KPV's ability to reduce inflammatory cytokines makes it relevant to inflammatory skin conditions including psoriasis-related autoimmune inflammation